Chemical constituents from Artemisia annua.
- Author:
Yi-wu ZHAO
;
Fu-yong NI
;
Ya-ling SONG
;
Sheng-yang WANG
;
Wen-zhe HUANG
;
Zhen-zhong WANG
;
Wei XIAO
- Publication Type:Journal Article
- MeSH: Artemisia annua; chemistry; Chromatography, Gel; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; chemistry; isolation & purification; Flavonoids; chemistry; isolation & purification; Medicine, Chinese Traditional; Plants, Medicinal; Quinic Acid; analogs & derivatives; chemistry; isolation & purification; Silica Gel
- From: China Journal of Chinese Materia Medica 2014;39(24):4816-4821
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the chemical constituents of dried whole plants of Artemisia annua.
METHODThe chemical constituents were isolated by repeated silica gel chromatography, medium pressure column chromatography, and semi-preparative HPLC, and their structures were elucidated by spectroscopic analyses and comparison of NMR data with those reported in literature.
RESULT15 compounds were isolated and identified to be 5-O-[(E)-Caffeoyl] quinic acid(l), 1,3-di-O-caffeoylquinic acid(2), 4 5-di-O-caffeoylquinic acid(3), 3, 5-di-O-caffeoylquinic acid (4), 3, 4-di-O-caffeoylquinic acid (5), methyl-3,4-di-O-caffeoylquinic acid(6), methyl-3,5-di-O-caffeoylquinic acid(7), 3,6'-O-diferuloylsucrose(8), 5'-β-D-glucopyranosyloxyjasmonic acid(9), Scopoletin(10), scoparone (11), 4-O-β-D-glucopyranosyl-2-hydroxyl-6-methoxyacetophenone (12), chrysosplenol D (13), casticin (14), chrysosplenetin(15).
CONCLUSIONCompounds 2, 6, 8 and 9 are obtained from the Artemisia genus for the first time. Compounds 7 and 15 are obtained from this plant for the first time.