Regulatory effect of leonurus extracts on hyperuricemia in rats.
- Author:
Man YAN
;
Ya-ting AN
;
Jian LI
;
Zhi-zhen WU
;
Tao WANG
- Publication Type:Journal Article
- MeSH:
Allopurinol;
pharmacology;
Animals;
Blood Urea Nitrogen;
Creatinine;
blood;
Disease Models, Animal;
Down-Regulation;
Gene Expression Regulation;
drug effects;
Hyperuricemia;
blood;
drug therapy;
Kidney;
drug effects;
Leonurus;
chemistry;
Male;
Organic Anion Transporters;
genetics;
Oxonic Acid;
administration & dosage;
Plant Extracts;
isolation & purification;
pharmacology;
Rats;
Rats, Sprague-Dawley;
Specific Pathogen-Free Organisms;
Up-Regulation;
Uric Acid;
blood
- From:
China Journal of Chinese Materia Medica
2014;39(24):4856-4859
- CountryChina
- Language:Chinese
-
Abstract:
In this study, SD rats were orally administrated with oteracil potassium (300 mg . kg-1 . d-1 ) to prepare the hyperuricemia model, and divided into normal, model, Allopurinol, LE high dosage, middle dosage and low dose (200, 100, 50 mg . kg-1 . d-1) groups. The rats were orally administrated with test drugs 1 hour later after being orally administrated with Oteracil potassium. After 7 days, serum uric acid, serum creatinine, uric acid and expression of relevant transporters in kidney were tested to study the regulatory effect of leonurus extracts on serum uric acid, renal function and relevant transporters in kidney of rats with hyperuricemia. Compared with the model group, the leonurus extract group could significantly down-regulate serum uric acid and creatinine levels of rats with hyperuricemia, and increase the urine uric acid level. Meanwhile, leonurus extracts could notably down-regulate the mRNA expressions of urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9), up-regulate the mRNA expressions of organic cation transportanter (OCT) and Carnitine transporter (OCTN) and promote the excretion of uric acid of kidney.
