Study on molecular mechanism of Euodiae Fructus on liver toxicity in MICE.

Author: Wen-qiang LIAO ; Bo LI ; Li LI ; Jun-ning ZHAO
Publication Type:Journal Article
MeSH: Alanine Transaminase; blood; Animals; Aspartate Aminotransferases; blood; Down-Regulation; Drugs, Chinese Herbal; toxicity; Evodia; chemistry; Female; Fruit; chemistry; Gene Expression Regulation; drug effects; Liver; drug effects; metabolism; Male; Mice; Plants, Medicinal; Signal Transduction; drug effects; Specific Pathogen-Free Organisms; Triglycerides; blood; Up-Regulation
From: China Journal of Chinese Materia Medica 2014;39(24):4865-4868
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo study the molecular mechanism of extracts from Euodia rutaecarpa on hepatotoxicity in mice.
METHODTotally 30 KM mice were divided into 3 groups and orally administrated extracts from E. rutaecarpa for consecutively 15 days. The expressions of Erkl/2, CDK8, CK1e, Stat3 and Src were detected by Western blotting method.
RESULTThe extracts from E. rutaecarpa could up-regulated Erkl/2, CDK8 and CK1e expressions (P <0.01) and down-regulate Stat3 and Src (P <0.01).
CONCLUSIONThe molecular mechanism of E. rutaecarpa on hepatotoxicity may be correlated with Erkl/2, CDK8, CKle, Stat3 and Src signal molecules.