Pharmaceutical research progress of rhynchophylla based on chemical stability.
- Author:
Bo HAO
;
Xiu-Juan YANG
;
Yi FENG
;
Yan-Long HONG
- Publication Type:Journal Article
- MeSH:
Animals;
Drug Stability;
Drugs, Chinese Herbal;
chemistry;
pharmacology;
Humans;
Quality Control;
Uncaria;
chemistry
- From:
China Journal of Chinese Materia Medica
2014;39(23):4532-4537
- CountryChina
- Language:Chinese
-
Abstract:
Rhynchophylla is a Chinese herb commonly used in clinical practice. It's also the primary herb of some famous Chinese herbal compound such as Tianma Gouteng decoction, and Lingyang Gouteng decoction. According the record from many previous materia medica literatures, rhynchophylla should be added later during decoction. Pharmaceutical research showed that rhynchophylla alkaloids were not stable. Which has resulted in many problems in the research and its application. For example, there was not a quantitative determination method in "Chinese Pharmacopoeia" of past and present versions, which seriously impacted its quality control and product application. Firstly, records from previous materia medica literatures and "Chinese Pharmacopoeia" were systematically sorted based on the chemical stability of rhynchophylla. Secondly, pharmaceutical research including chemical compositions and their stability, pharmacological effects, extraction process and quality analysis, was reviewed after reference of literatures published at home and abroad in recent decades. Positive reference and evidence for further research and development of rhynchophylla will be provided in the article.
