Metabolic syndrome and coronary artery calcification: a community-based natural population study.

Hui-li Cao; Xiong-biao Chen; Jin-guo LU; Zhi-hui Hou; Xiang Tang; Yang Gao; Fang-fang YU; Shi-liang Jiang; Lian-cheng Zhao; Ying LI; Matthew J Budoff; Robert Detrano; Bin LU

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Metabolic syndrome and coronary artery calcification: a community-based natural population study.

Author: Hui-Li CAO ¹ ; Xiong-Biao CHEN ¹ ; Jin-Guo LU ¹ ; Zhi-Hui HOU ¹ ; Xiang TANG ¹ ; Yang GAO ¹ ; Fang-Fang YU ¹ ; Shi-Liang JIANG ¹ ; Lian-Cheng ZHAO ² ; Ying LI ² ; Matthew J BUDOFF ³ ; Robert DETRANO ⁴ ; Bin LU ¹
Author Information

1. Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
2. Division for CVD Prevention and Control Network, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
3. Department of Internal Medicine, Division of Cardiology, Harbor-UCLA Medical Center, #1124 W Carson Street, Torrance 90502, CA, USA.
4. Department of Radiological Sciences and Program in Public Health, University of California, Irvine, California, USA.
Publication Type:Journal Article
MeSH: Adult; Aged; China; epidemiology; Coronary Artery Disease; epidemiology; metabolism; pathology; Coronary Vessels; metabolism; pathology; Female; Humans; Male; Metabolic Syndrome; epidemiology; metabolism; pathology; Middle Aged; Risk Factors
From: Chinese Medical Journal 2013;126(24):4618-4623
CountryChina
Language:English
Abstract:
BACKGROUNDLittle is known about the influence of metabolic syndrome (MetS) on coronary artery calcification (CAC) in China. In this article, we aimed to explore the distribution of CAC in populations with and without MetS, and estimate the influence of MetS and its components on CAC in a community-based population of Beijing.
METHODSA total of 1647 local residents of Beijing, age 40-77 years, were recruited for a cardiovascular risk factors survey and were determined fasting plasma glucose (FPG), blood lipids, and 64 multi-detector computed tomography (64-MDCT) coronary artery calcium score (CACS) measurement (Agatston scoring). The distribution of CAC was described, and the influence of MetS components on CAC was evaluated.
RESULTSIn this population, the prevalence and extent of CAC increased with increasing age and both were higher in MetS subjects compared to nonMetS subjects (all P < 0.05), with the exception of those older than 65 years old. The risk of CAC increased with increasing numbers of MetS components, and the odds ratios for predicting positive CAC in subjects with 1, 2, 3, and = 4 MetS components were 1.60, 1.84, 2.12, and 3.12, respectively (all P < 0.05). Elevated blood pressure, elevated FPG, elevated triglycerides, and overweight increased the risk of CAC, yielding odds ratios of 2.64, 1.67, 1.32, and 1.37, respectively (all P < 0.05).
CONCLUSIONSIn the Beijing community-based population, MetS increases the risk of CAC. The risk of CAC increases with increasing numbers of MetS components. Not only the number, but also the variety of risk factors for MetS is correlated with the risk of CAC. Elevated blood pressure, hyperglycemia, hypertriglyceridemia and overweight increase the risk of CAC.