The impact of microbubbles-mediated intermitten HIFU on bloodflow in femoral artery of rabbit.
- Author:
Yujuan YUE
1
;
Wenzhi CHEN
;
Zhibiao WANG
Author Information
1. The First Affiliated Hospital, Chongqing University of Medical Science, Chongqing 400016, China. grass220@163.com
- Publication Type:Journal Article
- MeSH:
Animals;
Blood Flow Velocity;
radiation effects;
Embolization, Therapeutic;
methods;
Female;
Femoral Artery;
pathology;
physiopathology;
radiation effects;
Male;
Microbubbles;
Rabbits;
Regional Blood Flow;
Ultrasonic Therapy;
methods
- From:
Journal of Biomedical Engineering
2010;27(1):58-61
- CountryChina
- Language:Chinese
-
Abstract:
This study sought to find out whether the femoral artery of rabbit could be occluded after microbubbles mediated intermitten ultrasound exposure. One hundred and eight rabbits were randomly divided into 3 groups subjected to 3 different factors, namely ultrasound, HIFU combined with Microbubble (the intermitten mode and the continuous mode). After exposure, HE staining was used for visual inspection of the histopathologic change of femoral artery. Electron microscope was used for observation of the ultramicrostructural change; digital subtraction radiography (DSA) was used for inspections of the change in blood flow. There were thrombi formed in the femoral artery and the blood flow was occluded; the endarterium of the femoral artery of rabbits was damaged, and there was cavitation observed in the intermitten exposure group. In the other two groups, there was no change in the the femoral artery of rabbits. Thrombus could be formed in the femoral artery, and blood flow was occluded after exposure to microbubbles-mediated intermitten HIFU.
