The effects of hypoxic-ischemia on glutamate transporters.
- Author:
Wen ZENG
1
;
Yi QU
;
Meng MAO
Author Information
1. Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- MeSH:
Amino Acid Transport System X-AG;
antagonists & inhibitors;
metabolism;
Animals;
Glutamate Plasma Membrane Transport Proteins;
metabolism;
Glutamic Acid;
metabolism;
Humans;
Hypoxia-Ischemia, Brain;
metabolism;
Synapses;
physiology;
Synaptic Transmission;
physiology
- From:
Journal of Biomedical Engineering
2010;27(1):202-205
- CountryChina
- Language:Chinese
-
Abstract:
Glutamate is a kind of excitatory transmitter in the central nervous system of mammals; at the same time, being with excitatory toxicity, its extracellular concentration is mainly modulated by the glutamate transporters. In the case of hypoxic-ischemia, the energy failure would lead to the generation of lactate and free radical, and to the crash of [Na+] gradient, thus exerting influence on the activity and the expression of glutamate transporters. As a result, the glutamate accumulates in the synaptic cleft, activates the glutamate receptors, and causes the death of neurons.
