A study of brain inner tissue water molecule self-diffusion model based on Monte Carlo simulation.
- Author:
Zhanxiong WU
1
;
Shanan ZHU
;
He BIN
Author Information
1. College of Electrical Engineering, Zhejiang University, Hangzhou 310027, China. wuzhanxiong@sohu.com
- Publication Type:Journal Article
- MeSH:
Body Water;
metabolism;
Brain;
metabolism;
Cell Membrane Permeability;
Diffusion;
Diffusion Magnetic Resonance Imaging;
methods;
Extracellular Space;
metabolism;
Humans;
Models, Biological;
Monte Carlo Method
- From:
Journal of Biomedical Engineering
2010;27(3):481-484
- CountryChina
- Language:Chinese
-
Abstract:
The study of water molecule self-diffusion process is of importance not only for getting anatomical information of brain inner tissue, but also for shedding light on the diffusion process of some medicine in brain tissue. In this paper, we summarized the self-diffusion model of water molecule in brain inner tissue, and calculated the self-diffusion coefficient based on Monte Carlo simulation under different conditions. The comparison between this result and that of Latour model showed that the two self-diffusion coefficients were getting closer when the diffusion time became longer, and that the Latour model was a long time-depended self-diffusion model.
