Value of Glasgow prognostic score in patients with adenocarcinoma of esophagogastric junction.
- Author:
Yao CUI
1
;
Jian LI
2
;
Mingyue LIU
1
;
Zuxuan SHI
1
;
Yaru FU
1
;
Lihong CAI
1
;
Tianhui GAO
3
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; C-Reactive Protein; Disease-Free Survival; Esophageal Neoplasms; Esophagogastric Junction; Humans; Kaplan-Meier Estimate; Prognosis; Retrospective Studies; Stomach Neoplasms
- From: Chinese Journal of Gastrointestinal Surgery 2016;19(1):54-57
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the prognosis and predictive values of preoperative Glasgow prognostic score (GPS) for adenocarcinoma of esophagogastric junction(AEG) patients.
METHODSA retrospective study of 322 AEG patients who received operation between January 2007 and March 2010 in Henan Provincial People's Hospital was performed. Clinical data, pathological characteristics, laboratory parameters and survival data were collected. The GPS was calculated based on C-reactive protein(CRP) and serum albumin(ALB) levels. Univariate and multivariate analysis were used to evaluate the prognostic value of GPS.
RESULTSAmong 322 patients, 0, 1, 2 of GPS were 192, 104 and 26 patients respectively. The median follow-up was 37 (4-73) months. In Kaplan-Meier analysis, median diseases-free survival (DFS) of GPS 0, 1, 2 was 47.0 (95% CI: 31.6-62.4), 15.0 (95% CI: 11.8-8.2) and 4.7 (95% CI: 3.8-5.6) months (P<0.01), and median overall survival (OS) was out of reach, 20.6 (95% CI: 15.8-25.4) and 7.0 (95% CI: 5.8-8.2) months (P<0.01). Univariate and multivariate analysis revealed that GPS was an independent predictor of DFS (P<0.01) and OS (P<0.01) of AEG.
CONCLUSIONGPS is an effective predictor of survival in AEG.
