Left Ventricular Strain as Predictor of Chronic Aortic Regurgitation.
- Author:
Sun Hee PARK
1
;
Young Ae YANG
;
Kyu Yeon KIM
;
Sang Mi PARK
;
Hong Nyun KIM
;
Jae Hee KIM
;
Se Yong JANG
;
Myung Hwan BAE
;
Jang Hoon LEE
;
Dong Heon YANG
Author Information
- Publication Type:Original Article
- Keywords: Chronic aortic regurgitation; Left ventricular strain; Mortality
- MeSH: Aortic Diseases; Aortic Valve; Aortic Valve Insufficiency*; Atrial Fibrillation; Blood Urea Nitrogen; Body Surface Area; Dilatation; Echocardiography; Follow-Up Studies; Heart Defects, Congenital; Humans; Mortality; Multivariate Analysis; Observational Study; Proportional Hazards Models; Retrospective Studies; Thoracic Surgery
- From:Journal of Cardiovascular Ultrasound 2015;23(2):78-85
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: It is not well known about the implication of left ventricular (LV) strain as a predictor for mortality in patients with chronic aortic regurgitation (AR). The purpose of this study was to investigate whether global longitudinal strain measured by two-dimensional speckle-tracking echocardiography could predict long-term outcome in patients with chronic AR. METHODS: This is a single center non-randomized retrospective observational study. The patients with chronic AR from January 2002 to December 2012 were retrospectively enrolled. Following patients were excluded; combined other significant valvular disease, previous heart surgery, aortic disease, congenital heart disease, acute AR and young age under 18 years old. Finally, 60 patients were analyzed and the LV global strain rate was measured on apical four chamber image (GS-4CH). RESULTS: During 64 months follow-up duration, 16 patients (26.7%) were deceased and 38 patients (63.3%) underwent aortic valve replacement (AVR). Deceased group was older (69 years old vs. 51 years old, p < 0.001) and had lower longitudinal strain (-12.05 +/- 3.72% vs. -15.66 +/- 4.35%, p = 0.005). Kaplan-Meier survival curve stratified by GS-4CH showed a trend of different event rate (log rank p = 0.001). On multivariate analysis by cox proportional hazard model adjusting for age, sex, body surface area, history of atrial fibrillation, blood urea nitrogen, LV dilatation, LV ejection fraction and AVR, decreased GS-4CH proved to be an independent predictor of mortality in patients with chronic AR (hazard ratio 1.313, 95% confidence interval 1.010-1.706, p = 0.042). CONCLUSION: GS-4CH may be a useful predictor of mortality in patient with chronic AR.
