Role of transrectal real-time tissue elastography in the diagnosis of prostate cancer.
- Author:
Zhang YAN
1
;
Tang JIE
;
Li YAN-MI
;
Fei XIANG
;
Cheng LIU-QUAN
;
He EN-HUI
;
Li QIU-YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Elasticity Imaging Techniques; methods; Humans; Male; Middle Aged; Predictive Value of Tests; Prostatic Neoplasms; diagnostic imaging; Rectum; diagnostic imaging; Sensitivity and Specificity
- From: Acta Academiae Medicinae Sinicae 2011;33(2):175-179
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the role of transrectal real-time tissue elastography (TRTE) in the diagnosis of prostate cancer (PCa).
METHODSEighty-four patients with suspected PCa and scheduled for prostate biopsies underwent TRTE, digital rectal examination (DRE), transrectal ultrasonography (TRUS), and magnetic resonance imaging (MRI). The findings of TRTE were compared with those of other examinations and pathological findings.
RESULTSOf these 84 patients, 36 had benign lesions and 48 had PCa. The diagnostic sensitivity, specificity, accuracy, positive predictive value and negative predictive value were 91.7%, 72.2%, 83.3%, 81.5%, and 86.7% for TRTE and 85.4%ì63.9%ì76.2%, 75.9%, and 76.7% for TRUS (P>0.05), while its specificity (72.2%) was significantly higher than that of MRI (44.4%) (P=0.03). The TRTE findings were not significantly correlated with the pathological findings and serum total prostate specific antigen (P>0.05), and the diagnostic sensitivity of TRTE decreased along with the enlargement of prostate. However, the diagnostic specificity of TRTE was higher than MRI for nodules with soft to medium texture (P=0.04).For PCa, the diagnostic sensitivity of TRTE increased when the Gleanson scores of tumors increased (P<0.05).
CONCLUSIONTRTE can be used as a diagnostic test to supplement clinical diagnosis of PCa.
