Polymorphism of 17 short tandem repeat Loci of Tibetan minority ethnic group from Lhasa.
- Author:
Jun MA
1
;
Hua-jie BA
;
Wen-jie ZHANG
;
Kai LI
Author Information
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; genetics; Ethnic Groups; genetics; Gene Frequency; Genotype; Humans; Microsatellite Repeats; genetics; Minority Groups; Polymorphism, Genetic; Tibet
- From: Acta Academiae Medicinae Sinicae 2011;33(4):397-401
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the polymorphism of 17 short tandem repeat (STR) loci of Tibetan minority ethnic group from Lhasa.
METHODSBlood samples were obtained from 132 unrelated Tibetan individuals from Lhasa. DNA templates were screened by home-made AGCU17+1 kit and 3130XL genetic analyzer. Genotyping was performed using GeneMapper software (version 3.2).
RESULTSThe allele frequencies of 17 STR loci ranged 0.0038-0.5720, and the power of discrimination ranged 0.779-0.979, the power of exclusion ranged 0.327-0.737, the polymorphism information contents ranged 0.538-0.910, and the heterozygosity ranged 0.629-0.871. The cumulative coupling probability was 3.93 × 10(-20), and the cumulative power of exclusion was 0.9999995234. Of 17 STR loci, Penta E and D6S1043 had the highest polymorphism indicators, while TPOX had the lowest.
CONCLUSIONThe 17 STR loci used in this study are highly polymorphism in Tibetan minority ethnic group from Lhasa and fit for the population genetic study and forensic cases.
