Evaluation of the liver reserve using lidocaine test on experimental liver injuries in rats.
- Author:
Zhen-xia WANG
1
;
Rui-ming ZHANG
;
Lü-nan YAN
;
Wen-tao WANG
;
Qian-bin JIA
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Lidocaine; analogs & derivatives; Liver; pathology; physiopathology; Liver Cirrhosis, Experimental; chemically induced; pathology; physiopathology; Liver Function Tests; Male; Random Allocation; Rats; Rats, Wistar
- From: Chinese Journal of Hepatology 2006;14(6):445-448
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESTo study the effectiveness of the lidocaine test in evaluating the liver reserve of rats with experimental liver injury in different phases.
METHODS40 healthy male Wistar rats were divided randomly into experimental and control groups. Rats of the experimental group received subcutaneous CCl4 in oil injection, and rats of the control group received saline injections. Monoethylglycinexylidide (MEGX) test, common hepatic function tests and histological examination of the livers were performed on all the rats.
RESULTSWith the development of the severity in liver injury, the concentrations of the serum MEGX in lidocaine test decreased gradually, which were consistent with liver histological changes. However, the results from the common liver function tests were all abnormal in the experimental group and were not consistent with the liver histological changes.
CONCLUSIONThe results obtained from the MEGX test are more agreeable to liver histological changes than those from common liver function tests. The results from the MEGX test can represent liver histological changes concisely.
