Studies on the association between beta 2-glycoprotein I and hepatotropism of hepatitis B virus.
- Author:
Yan-hang GAO
1
;
Pu-jun GAO
;
Dan WANG
;
Yang SHI
;
Tong-yu TANG
;
Yun-feng PIAO
;
Han-yi YANG
Author Information
- Publication Type:Journal Article
- MeSH: Hepatitis B; virology; Hepatitis B Surface Antigens; metabolism; Hepatitis B virus; pathogenicity; Humans; Viral Envelope Proteins; blood; beta 2-Glycoprotein I; blood
- From: Chinese Journal of Hepatology 2006;14(8):569-571
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo further study the binding character of hepatitis B surface antigen (HBsAg) and beta 2-glycoprotein I (beta2GP I) and to explore whether beta2GP I plays an important role in the hepatotropism of hepatitis B virus.
METHODSUsing Western blot technique, we observed the binding character of the HBsAg with reduced and non-reduced beta2GP I.
RESULTSrHBsAgs with reduced and non-reduced beta2GP I showed identical binding activity.
CONCLUSIONSThe binding activity of HBsAg is dependent on tandem residues, but not on conformational structures of beta2GP I. There is a specific binding between HBV and beta2GP I, which may play an important role in HBV infection and is one of the reasons of hepatotropism of HBV.
