Sodium channel changes in human atrial cells isolated from various ages

VernacularTitle:人心房肌细胞钠通道的增龄性变化
Author: Qi-Yong LI ¹ ; Rong-Jian JIANG ; Li CHEN ; Hong KONG ; Jin-Chuan LAI ; Biao CHENG ; Yan SHU
Author Information

1. 四川省医学科学院,四川省人民医院
Keywords: Atrial fibrillation; Sodium channels; Patch-clamp techniques
From: Chinese Journal of Cardiology 2010;38(1):57-59
CountryChina
Language:Chinese
Abstract: Objective To investigate if the increased incidence of atrial fibrillation with age was associated with changes of Na~+ channel in atrial myocytes. Methods Twenty-three patients underwent valve replacement operations were divided into adult [<60 years, n = 15, 9 males, mean age(42.1±7.1) years] and aged group [≥160 years, n = 8, 5 males, mean age (63.3±3.1) years]. All patients were in normal sinus rhythm. Whole cell patch clamp techniques were used to record the Na~+ currents (I_(Na)) of right auricle myocytes. Results Both current density and time-dependent recovery of I_(Na). were similar in the cells from the 2 groups. Voltage-dependent inactivation of I_(Na) of myocytes in the aged atria was shifted to more positive voltages. Conclusion Current density of I_(Na) was similar between the 2 age groups, and Na~+ channel might not be an important determinant for the increased incidence of atrial fibrillation in aged patients.