Value of estimated glomerular filtration rate and serum creatinine for predicting long-term survival in Chinese patients after isolated coronary artery bypass graft surgery.
- Author:
Ye LIN
1
;
Zhe ZHENG
;
Sheng-Shou HU
;
Jian-Ping XU
;
Feng LÜ
;
Wei WANG
;
Yun-Hu SONG
;
Han-Song SUN
;
Xin YUAN
;
Xiang-Bin PAN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Asian Continental Ancestry Group; Cause of Death; Coronary Artery Bypass; Creatinine; blood; Female; Glomerular Filtration Rate; Hospital Mortality; Humans; Kidney Function Tests; methods; Male; Middle Aged; Postoperative Period; Predictive Value of Tests; ROC Curve; Renal Insufficiency; diagnosis; etiology; mortality; Retrospective Studies; Risk Factors; Young Adult
- From: Chinese Journal of Cardiology 2010;38(2):99-102
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the predictive value of glomerular filtration rate (GFR) estimated by the Cockcroft-Gault formula or the modification of diet in renal disease (MDRD) equation and serum creatinine for in-hospital and long-term mortality post coronary artery bypass graft surgery (CABG).
METHODSClinical data of 5559 consecutive patients undergoing isolated CABG were retrospectively analyzed. The main outcomes were in-hospital mortality and long-term mortality. Estimated GFR was calculated by the Cockcroft-Gault formula and MDRD equation respectively. Receiver-operating characteristic curves and Cox's analysis were used for the comparison.
RESULTSFollow-up was complete in 5485 patients (97.6%). Analysis of receiver-operating characteristic curves showed that GFR estimated by the Cockcroft-Gault formula had a maximal accuracy for predicting in-hospital mortality (area under the curve: 0.755, P < 0.01). Multivariate logistic analysis and the Cox's analysis results indicated estimated GFR < 60 mlxmin(-1)x1.73 m(-2) base on the Cockcroft-Gault formula was an independent risk factor for in-hospital and long-term mortality (hazard ratio 4.51 for in-hospital mortality, P < 0.01; hazard ratio 1.54 for long-term mortality, P < 0.01), both Cockcroft-Gault formula and MDRD equation were superior to serum creatinine for predicting in-hospital and long-term mortality post CABG.
CONCLUSIONGFR estimated by the Cockcroft-Gault formula was superior to GFR estimated by the MDRD equation for predicting in-hospital mortality, and estimated GFR was superior to serum creatinine for predicting in-hospital and long-term mortality.
