Value of estimated glomerular filtration rate and serum creatinine for predicting long-term survival in Chinese patients after isolated coronary artery bypass graft surgery
10.3760/cma.j.issn.0253-3758.2010.02.002
- VernacularTitle:三种不同肾功能评估方法对冠状动脉旁路移植术后死亡的预测
- Author:
Ye LIN
1
;
Zhe ZHENG
;
Sheng-Shou HU
;
Jian-Ping XU
;
Feng L(U)
;
Wei WANG
;
Yun-Hu SONG
;
Han-Song SUN
;
Xin YUAN
;
Xiang-Bin PAN
Author Information
1. 中国医学科学院北京协和医学院心血管病研究所阜外心血管病医院
- Keywords:
Coronary artery bypass;
Renal insufficiency;
Glomerular filtration rate
- From:
Chinese Journal of Cardiology
2010;38(2):99-102
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the predictive value of glomerular filtration rate (GFR)estimated by the Cockcroft-Gault formula or the modification of diet in renal disease (MDRD) equation and serum creatinine for in-hospital and long-term mortality post coronary artery bypass graft surgery (CABG).Methods Clinical data of 5559 consecutive patients undergoing isolated CABG were retrospectively analyzed. The main outcomes were in-hospital mortality and long-term mortality. Estimated GFR was calculated by the Cockcroft-Gault formula and MDRD equation respectively.Receiver-operating characteristic curves and Cox's analysis were used for the comparison.Results Follow-up was complete in 5485 patients (97.6%).Analysis of receiver-operating characteristic curves showed that GFR estimated by the Cockcroft-Gault formula had a maximal accuracy for predicting in-hospital mortality (area under the curve:0.755,P＜0.01).Multivariate logistic analysis and the Cox's analysis results indicated estimated GFR＜60 ml ·min~(-1)·1.73 m~(-2) base on the Cockcroft-Gault formula was an independent risk factor for in-hospital and long-term mortality(hazard ratio 4.51 for in-hospital mortality,P＜0.01 ;hazard ratio 1.54 for long-term mortality,P＜0.01),both Cockcroft-Gault formula and MDRD equation were superior to serum creatinine for predicting in-hospital and long-term mortality post CABG.Conclusion GFR estimated by the Cockcroft-Gault formula was superior to GFR estimated by the MDRD equation for predicting in-hospital mortality,and estimated GFR was superior to serum creatinine for predicting in-hospital and long-term mortality.
