Analysis of therapeutic effects of rural patients with hypertension by combination administration of low dosage of hydrochlorothiazide and nitrendipine
10.3760/cma.j.issn.0253-3758.2010.02.010
- VernacularTitle:小剂量氢氯噻嗪联合尼群地平治疗农村地区高血压疗效分析
- Author:
Zhao-Qing SUN
1
;
Li-Qiang ZHENG
;
Da-Yi ZHANG
;
Xin-Zhong ZHANG
;
Xin-Gang ZHANG
;
Shuang-Shuang LIU
;
Chang-Lu XU
;
Jue LI
;
Da-Yi HU
;
Ying-Xian SUN
Author Information
1. 中国医科大学附属盛京医院
- Keywords:
Hypertension;
Hydrochlorothiazide;
Nitrendipine;
Rural population
- From:
Chinese Journal of Cardiology
2010;38(2):135-138
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the therapeutic effects of combination administration of hydrochlorothiazide and nitrendipine at low dosage in the treatment of rural hypertension patients.Methods By the method of cluster random sampling,5292 primary hypertension patients from Fuxin,Liaoning Province were divided into health education group(control group)and drug intervention group in June 2006.The drug intervention group were treated with hydrochlorothiazide,nitrendipine and captopril by stepwise approach and we observe the antihypertensive effect of drug and the effect on the onset of stroke.Results The average follow-up time was 15 months.At last,308 patients were lost to follow-up(the lost follow-up rate was 5.8 percent).The 4984 in cohort,including 2530 of intervention group and 2454 of control group,had examination of all indicators.Through health education and drug intervention,the average blood pressure in drug intervention group decreased by 16.1/9.4 mm Hg(1 mm Hg=0.133 kPa)while the average blood pressure in control group decreased by 6.7/3.5 mm Hg.The control rate of blood pressure in drug intervention group was higher than control group(33.1%vs.15.1%,P＜0.001).Through drug intervention,the morbidity risk of nonfatal stroke in drug intervention group decreased by 57.3%compared to control group,the total morbidity risk of stroke decreased by 59.4%.The results had significant statistical difference.And,the morbidity of severe hypopotassaemia(K~+＜3.0 mmol/L)and diabetes mellitus had no significant statistical diffefence between two groups.Conclusions The low-cost antihypertensive program based on thiazide had good antihypertensive effect,high safety and good cost-effect ratio.The program could be used in rural areas of China.
