Positive rate of autoantibodies against adrenergic receptors β1 and angiotensin Ⅱ type 1 receptors in the type 2 diabetes mellitus with or without hypertension
10.3760/cma.j.issn.0253-3758.2010.02.011
- VernacularTitle:2型糖尿病伴左心室扩大患者与血清抗β1和抗血管紧张素Ⅱ1型受体自身抗体的关系
- Author:
Lin-Shuang ZHAO
1
;
Yu-Hua LIAO
;
Guang-Da XIANG
;
Min WANG
;
Ling YUE
;
Zi-Hua ZHOU
;
Hui-Ling SUN
Author Information
1. 解放军广州军区武汉总医院
- Keywords:
Diabetes mellitus,type 2;
Hypertension;
Hypertrophy,left ventricular;
Receptors,adrenergic,bata-1;
Receptors,angiotensin
- From:
Chinese Journal of Cardiology
2010;38(2):139-142
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the positive rates of autoantibodies against β1 adrenergic receptors(β1-receptor)and angiotensin Ⅱ type 1 receptors(AT1-receptor)in type 2 diabetes patients with or without hypertension.Methods The epitopes of the second extracellular loop of β1-receptor(197-222)and AT_1 receptor(165-191)were synthesized and serum autoantibodies were determined in type 2 diabetes patients with hypertension(n=171)or without hypertension(n=106).Left ventricular dimansion was determined by echocardiography.The 24-hour urinary protein was measured by ELISA.The risk factors for enlarged left ventricle were analyzed by multiple logistic regressions.Results The positive rates of the autoantibodies against β1-receptors(45.0%)and AT_1-receptor(46.2%)in patients with type 2 diabetes with hypertension were significantly higher than those in patients with type 2 diabetes without hypertension (16.0%and 10.4%,respectively,all P＜0.01).In type 2 diabetes patients with hypertension and enlarged left ventricle,the positive rates of the autoantibodies against β1-receptor 61.4%(35/57)and against AT_1-receptor 64.9%(37/57)were significantly higher than those in type 2 diabetes patients with normal left ventricular dimension(36.8%,42/114 and 36.8%,42/114,respectively,all P＜0.01).Regression analysis demonstrated that course of disease,systolic pressure,serum autoantibodies against β1 adrenergic receptor and angiotensin Ⅱ type 1 receptors seraautoantibodies were independent risk factors for Jeft ventricular enlargment(all P＜0.05).Conclusion The scram β1 and AT_1-receptor autoantibodies are related to enlarged left ventricle in type 2 diabetes patients with hypertension and suggest that autoantibodies against β1 and AT_1-receptor might play important roles in the pathogenesis of type 2 diabetes patients with hypertension and enlarged left ventricle.
