Atrovastatin use and coronary flow reserve in patients with coronary slow flow
10.3760/cma.j.issn.0253-3758.2010.02.012
- VernacularTitle:阿托伐他汀对冠状动脉血流缓慢患者冠状动脉血流储备的影响
- Author:
Ying FAN
1
;
Shu-Sen YANG
;
Jiang-Bo YU
;
Jin-Hong HAO
;
Wei HAN
;
Run-Tao CAN
;
Zheng WANG
;
Wei-Min LI
;
Yong-Lin HUANG
Author Information
1. 哈尔滨医科大学附属第一医院
- Keywords:
Coronary circulation;
Antilipemic agents;
Fractional flow reserve,myocardial
- From:
Chinese Journal of Cardiology
2010;38(2):143-146
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of statin use on coronary flow reserce(CFR)in patients with slow coronary flow.Methods A total of 91 patients with chest pain and coronary slow flow but normal coronary angiography were included in this study,patients were divided into statin group(atrovastatin 20 ms/d for 8 weeks,n=51)and non-statin group(n=40),26 healthy subjects with normal angiography and negative exercise ECG test served as normal controls.Blood cholesterol was measured.Doppler coronary flow velocity and Doppler reserve measurement of distal left anterior descending were recorded at rest and adenosine infusion(140 μg·kg~(-1)·min~(-1))induced hyperemia state,CFR was calculated by the ratio of maximal hyperemia and baseline peak diastolic coronary flow velocity(hCFV and bCFV)before and after atrovastatin treatment.Results (1)Eight weeks later,total cholesterol and LDL-C levels were significantly lower in statin group than in non-statin group and control group[TC(3.83±0.80)mmol/L vs.(5.30±1.18)mmol/L vs.(5.32±1.17)mmol/L,P＜0.05;LDL-C(2.26±0.64)mmol/L vs.(3.28±0.85)mmoL/L vs.(3.30±0.82)mmol/L,P＜0.05].(2)Baseline CFR levels were significantly lower in statin group and non-statin group than that in control group(2.32±0.30 vs.2.25±0.33 vs.3.15±0.34,P＜0.05).Compared with non-statin group and statin group before treatment,8 weeks statin treatment was associated with reduced bCFV[(26.06±3.22)cm/s vs.(29.02±3.36)cm/s and(26.06±3.22)cm/svs.(28.43±3.40)cm/s,P＜0.05],increased hcFV[(77.63±8.96)cm/s vs.(65.17±7.22)cm/sand(77.63±8.96)cm/s vs.(64.58±6.26)cm/s,P＜0.05]and increased CFR(3.07±0.29 vs.2.28±0.35 and 3.07±0.29 vs.2.32±0.30,P＜0.05).bCFV,hCFV and CFR of statin group post treatment were similar to those of controls(P＞0.05).Conclusion Patients with coronary slow flow were associated with lower CFR which could be significantly improved by statin therapy.
