Throat infection,neck spinal disease, chest pain and cardiac response: a new clinical syndrome?
10.3760/cma.j.issn.0253-3758.2010.02.013
- VernacularTitle:咽、颈、胸痛与心脏反应新的临床综合征?
- Author:
Chang-Qing ZHOU
1
;
Jiang-Tao YAN
;
Qiao FAN
;
Zhou-Ya LI
;
Cianflone KATHERINE
;
Dao-Wen WANG
Author Information
1. 安徽省合肥市第一人民医院
- Keywords:
Inflammation;
Chest pain;
Cardiac response;
Diagnosis
- From:
Chinese Journal of Cardiology
2010;38(2):147-151
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the characteristics of a new clinical syndrome,including throat infection,neck spinal disease,chest pain and cardiac response.Methods A total of 65 patients with above mentioned symptoms admitted to Tongii hospital from 2003 to 2005 were included in this study and underwent further medical history inquiry,physical examination and laboratory tests.Eighty-five healthy subjects served as controls.Serum myocardial auto-antibodies against beta1-adrenoceptor,alpha-myosin heavy chain,M_2-muscarinic receptor and adenine-nucleotide translocator were detected,inflammatory cytokines,high sensitivity C-reaction protein,serum antibodies against Coxsackie virus-B,cytomegalovirus,Mycoplasma pneumoniae and Chlamydia pneumoniae were determined and lymphocyte subelasses were assayed by flow cytometry.Results All patients had a complex of four symptoms or tetralogy:(1)persistent throat or upper respiratory tract infection;(2)neck pain;(3)chest pain;(4)chest depression or dyspnea,some of them with anxiety.Anti-myocardial auto-antibodies(AMCA)were present in all patients vs.8% in controls.TNF-a,IL-1 and IL-6 were significantly higher in patients than controls(P＜0.01).CD3~+ and CD4~-CD8~+ lymphocytes were significantly higher and CD56~+ lymphocytes lower in patients than those in controls(P＜0.01).The ratios of serum pathogen antibodies positive against Coxsackic virus-B,cytomegalovirus,Mycoplasma pneumoniae and Chlamydia pneumoniae were all significantly higher in patients than in controls.Conclusions These data led to identification of a persistent respiratory infectionrelated clinical syndrome,including persistent throat infection,neck spinal lesion,rib cartilage inflammation,symptoms of cardiac depression and dyspnea with or without anxiety.
