Value of Doppler echocardiography derived myocardial energy expenditure measurements in chronic heart failure patients
10.3760/cma.j.issn.0253-3758.2010.03.003
- VernacularTitle:多普勒超声心动图检测慢性心力衰竭患者心肌生物能量消耗水平的变化及临床意义
- Author:
An-Na SHEN
1
;
Zhi-Yong DU
;
Peng WANG
;
Zhi-Bin XIE
;
Ding-Li XU
Author Information
1. 南方医科大学南方医院
- Keywords:
Heart failure,congestive;
Echocardiography,Doppler;
Myocardial energy expenditure
- From:
Chinese Journal of Cardiology
2010;38(3):209-214
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between myocardial energy expenditure(MEE) level and cardiac function in chronic heart failure (CHF) patients. Methods A total of 99 CHF patients were divided into 3 groups according to the LVEF ( HFNEF≥50% , n = 37; HFREF1 35. 1% -49.9% , n=30; HFREF2 ≤35% , n=32) or the New York Heart Association (NYHA Ⅱ, n=26;Ⅲ ,n=42; Ⅳ, n =31) criteria. Thirty patients with cardiovascular disease and without CHF served as controls. Routine examinations including serum CRP (ELISA) and plasma NT-proBNP (chemiluminescence sandwich ELJSA) were made on the next morning after admission; echocardiography was performed on the third day after admission. LVMW, LVMWI, RWT, LVIDd, LA, LV, LVEF, LVFS, E/A, EDT, IVRT, Tei index and MEE were measured or calculated. Results MEE was significantly higher in HFREF patients than in controls (P < 0.01) and similar between HFNEF patients and controls (P > 0.05). MEE increased in proportion to decrease of LVEF and increase of NYHA grades in CHF patients (all P < 0.05 ) . Bivariate analysis confirmed that MEE was significant correlated with LVMW, LVMWI, RWT, LVIDd, LA, LV, LVEF (r=- 0.540, P<0.01), LVFS (r= -0.454, P<0.01), E/A, EDT, IVRT, Tei index, NYHA grades, CRP and NT-proBNP. Conclusion MEE derived from standard echocardiographic measurements is an effective indicator for myocardial bioenergetics and significantly correlated with cardiac function in CHF patients, especially in CHF patients with reduced LVEF.
