Prospective study on associations between levels of total cholesterol, triglyceride and risk of ischemic and hemorrhagic strokes
10.3760/cma.j.issn.0253-3758.2010.03.014
- VernacularTitle:总胆固醇及甘油三酯与卒中亚型关系的前瞻性研究
- Author:
Bin JIANG
1
;
Xiang-Hua FANG
;
Yun-Hai LIU
;
Xiu-Ying DAI
;
Zhi-Guo LIN
;
Fang-Zhong SU
;
Qi-Dong YANG
;
Wen-Zhi WANG
;
Sheng-Ping WU
;
Shi-Chuo LI
Author Information
1. 首都医科大学
- Keywords:
Cerebrovascular accident;
Cholesterol;
Hypertriglyceridemia;
Prospective study
- From:
Chinese Journal of Cardiology
2010;38(3):268-271
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore associations between levels of total cholesterol (TC), triglyceride (TG) and incidence of ischemic and hemorrhagic strokes in populations. Methods Baseline investigations on stroke-related risk factors and physical examinations were performed in 10 093 ( > 35 years) stroke-free urban community residents from 5 cities in China during May to July in 1987, follow-up investigations on stroke events were made during 1998 to 2000. The hazard ratios and 95% confidence intervals (CI) of iachemic and hemorrhagic strokes in middle, high tertiles of baseline TC or TG levels were compared with low baseline tertile residents using the Cox regression model. Results There were 491 first strokes during the 8-years cohort follow-up. Compared with the low tertile, risk of ischemic stroke in the middle and high tertiles of TC level was increased by 61% ( HR: 1.61,95% CI: 1.14 -2. 27) and 58% (HR: 1.58, 95% CI: 1.12 -2. 22) after adjustments for DBP, age, sex and other variables in the Cox proportional hazards model. Compared with the low tertile, risk of ischeroic stroke in the high tertile of TG level was increased by 43% (HR: 1.43, 95% CI: 1.02 -2.00). However, risk of hemorrhagic stroke in the middle and high tertiles of TC level decreased by 12% (HR: 0.88, 95% CI: 0.64-1.22) and 33% (HR: 0.67, 95% CI:0. 48 - 0. 95) compared with the low tertile. Conclusions Elevated serum TC and TG are independent risk factors for risk of ischemie stroke. However, low TC was related with increased risk of hemorrhagic stroke.
