Impact of application time of aspirin and clopidogrel on platelet aggregation in patients with acute coronary syndrome
10.3760/cma.j.issn.0253-3758.2010.04.009
- VernacularTitle:阿司匹林和氯吡格雷不同服药时间对急性冠状动脉综合征患者血小板聚集率昼夜节律变化的影响
- Author:
Zhen LI
1
;
Fan LIU
;
Wei CUI
;
Rui-Qin XIE
;
Xiu-Chun YANG
;
Jing-Chao LU
;
Hong-Mei ZHENG
;
Xiao-Juan REN
;
Jing LIU
Author Information
1. 石家庄市第二医院
- Keywords:
Coronary disease;
Aspirin;
Platelet aggregation inhibitors;
Platelet aggregation
- From:
Chinese Journal of Cardiology
2010;38(4):311-314
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the impact of various application time of aspirin and clopidogrel on the circadian rhythm changes of platetet aggregation in patients with acute coronary syndrome.Methods Patients with acute coronary syndrome were divided into day-time (8:00) and night-time (20:00)medication group (n = 15 each).After plasma concentration reached steady state,platelet aggregation was assessed at 5 time points within 24 hours with a mobile four-channel whole blood impedance aggregometer.The plateht aggregation was induced by ADP and arachidonic acid.Thereafter,the two groups were exchanged and platelet aggregation was assessed in the same way post plasma steady state.Results Arachidonic acid-induced platelet aggregation was the highest at 10:00 Am[(7.96±3.64) ohm]and the lowest at 0:00[(6.12±3.29)ohm,P＞0.05]in day-time group.Platelet aggregation was the highest at 20:00[(9.40±5.39)ohm]and the lowest at 10:00[(5.46±3.93)ohm],P ＜0.05).ADP- induced platelet aggregation was the highest at 10:00 and the lowest at 16:00 in day-time group (P＞0.05) and was the highest at 20:00 and the lowest at 10:00 in night-time group(P ＞0.05).Platelet aggregation induced by two inducers was significantly higher at 10:00 in day-time group compared to values in night-time group(all P＜0.05).Conclusion Taking aspirin and clopidogrel at 20:00 was superior to taking the same medications at 8:00 for inhibiting peak platelet aggregation in the morning.
