Heart rate variability ,adrenomedullin and B-type natriuretic peptide before and after transcatheter closure in children with patent ductus arteriosus
10.3760/cma.j.issn.0253-3758.2010.04.014
- VernacularTitle:动脉导管未闭患儿介入封堵前后心率变异性及血浆肾上腺髓质素、B型利钠肽的变化
- Author:
Rong-Zhou WU
1
;
Xing RONG
;
Yue REN
;
Xu-Xiang HE
;
Ru-Lian XIANG
Author Information
1. 温州医学院附属第二医院,附属育英儿童医院
- Keywords:
Ductus arteriosus,patent;
Heart rate;
Adrenomedullin;
Natriuretic peptide,brain
- From:
Chinese Journal of Cardiology
2010;38(4):334-336
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of heart rate variability (HRV),adrenomedullin (ADM) and B-type natriuretic peptide(BNP) before and after transcatheter closure in children with patent ductus arteriosus.Methods HRV spectral values (TF,VLF,LF,HF,LF/HF) were detected by 24 dynamic electrocardiogram and the concentrations of plasma ADM and BNP were measured in 55 children with patent ductus arteriosus(Group PDA,n =55) before and 3~(rd) day,3~(rd) month after transcatheter closure therapy,and in 60 normal children (Group C).Results (1) Compared with Group C,the HRV spectral values (TF,VLF,HF)were significantly lower (all P＜0.01),LF/HF and the concentrations of plasma ADM,BNP were significantly higher in patients with PDA before transcatheter closure (all P＜0.01).(2) Compared with the values before transcatheter closure values,plasma ADM were significantly reduced at 3~(rd) day and 3~(rd) month after transcatheter closure(P＜0.01),the HRV spectral values (TF,VLF,HF) were significantly increased while LF/HF and plasma BNP were significantly decreased at 3~(rd) month after transcatheter closure (P＜0.01 or P＜0.05).Conclusions HRV and plasma ADM,BNP improved significantly post tnmscatheter closure in children with patent ductus arteriosus.
