Impact of growth-factor hormone control on the outcome of acromegalic cardiomyopathy
10.3760/cma.j.issn.0253-3758.2010.04.019
- VernacularTitle:肢端肥大症性心肌病二例的临床诊治和文献回顾
- Author:
Qiu-Fang SHE
1
;
Rong BAI
;
Qiang ZHOU
;
Jiang-Tao YAN
;
Dao-Wen WANG
Author Information
1. 华中科技大学同济医学院附属同济医院
- Keywords:
Cardiomyopathies;
Acromegaly;
Heart failure,congestive
- From:
Chinese Journal of Cardiology
2010;38(4):354-356
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the impact of growth-factor hormone control on the outcome of acromegalic cardiomyopathy by reviewing cases from our own center and from literatures.Methods Two cases of acromegalic cardiomyopathy from Tongji hospital and 29 acromegalic cardiomyopathy cases with fully accessible data retrieved from PnbMed and CNKI websites were included in present study for analysis.They were divided into "Controlled (＜5 μg/L)" or "Uncontrolled" group according to the serum level of growth factor hormone after treatments.Outcome of patients was evaluated by symptom,NYHA class,LV size and function status.Results Incidence of patients with improved symptoms and cardiac performance was significantly higher in "Controlled" group (18/19) compared to those in "Uncontrolled" group (0/12;P ＜0.01,χ~2 = 27.1).Post-treatment growth-factor hormone level＜5 μg/L is significantly associated with a satisfactory outcome of acromegaiic cardiomyopathy (r = 0.935,P＜0.01).Conclusions Control of serum growth-factor concentration to a value＜5 μg/L is critical and associated with a favorable outcome for patients with acromegalic cardiomyopathy.
