Comparison of right atrial matrix metalloproteinase expression between patients with unstable angina and myocardial infarction.
- Author:
Wei WANG
1
;
Ping-sheng WU
;
Xi-li YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Angina, Unstable; metabolism; Female; Gene Expression Regulation; Heart Atria; metabolism; Humans; Male; Matrix Metalloproteinase 1; metabolism; Matrix Metalloproteinase 3; metabolism; Matrix Metalloproteinase 7; metabolism; Matrix Metalloproteinase 9; metabolism; Middle Aged; Myocardial Infarction; metabolism; Tissue Inhibitor of Metalloproteinase-1; metabolism; Up-Regulation
- From: Chinese Journal of Cardiology 2010;38(5):411-414
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare right atrial structural remodeling and the expression of matrix metalloproteinase (MMP) and tissue inhibitors (TIMP) between patients with unstable angina (UA) and myocardial infarction (MI).
METHODSRight atrial appendages were obtained from 18 patients with UA and 22 patients with MI undergoing coronary artery bypass grafting (CABG) operations. MMP-1, -3, -7, -9 and TIMP-1 protein expressions were detected by immunohistochemistry and RT-PCR. Echocardiography was performed before CABG.
RESULTSThe left and right atrial diameter, left ventricular diameter and mRNA levels of MMP-3, MMP-9 and TIMP-1 were significantly higher in MI group than those in UA group [LAD: (40.8 +/- 4.2) mm vs. (33.1 +/- 5.1) mm, P < 0.01; RAD: (44.1 +/- 6.8) mm vs. (28.8 +/- 6.0) mm, P < 0.01; LVEDD: (48.9 +/- 6.0) mm vs. (39.7 +/- 7.1) mm, P < 0.05; MMP-3: 0.39 +/- 0.18 vs. 0.28 +/- 0.07, P < 0.05; MMP-9: 0.81 +/- 0.21 vs. 0.55 +/- 0.20, P < 0.01; TIMP-1: 1.79 +/- 0.89 vs. 0.94 +/- 0.47, P < 0.01]. MMP-1, MMP-7 levels were similar between the 2 groups (MMP-1: 0.14 +/- 0.06 vs. 0.10 +/- 0.08, P > 0.05; MMP-7: 0.25 +/- 0.05 vs. 0.23 +/- 0.06, P > 0.05).
CONCLUSIONRight atrial up-regulation of MMP-3, MMP-9 and TIMP-1 levels may contribute to the right atrial structural remodeling in MI patients.
