Elevated Vascular Endothelia Growth Factor-A in the Serum and Peritoneal Fluid of Patients with Endometriosis
10.1007/s11596-009-0520-7
- Author:
WANG HONGBO
1
;
Gorpudolo NOWIAH
;
LI YANHUI
;
FENG DILU
;
WANG ZEHUA
;
ZHANG YUAN
Author Information
1. Department of Obstetrics and Gynecology, Union Hospital Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022, China
- Keywords:
vascular endothelial growth factor-A;
endometriosis;
peritoneal fluid;
reproduction
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2009;29(5):637-641
- CountryChina
- Language:Chinese
-
Abstract:
There has been emergence of evidence suggesting that specific variants of the vascular en-dothelia growth factor (VEGF) family, based on their ability to regulate angiogenesis, would be pivotal in the pathogenesis of endometriosis. This study was aimed at determining whether high levels of VEGF-A could be found in the serum and peritoneal fluid (PF) of patients with endometriosis. VEGF-A levels were measured by enzyme-linked immunosorbent assay (ELISA) in serum and PF from 46 pa-tients with surgically confirmed endometriosis, and 40 controls with no clinical evidence of the disease or detectable endometriotic lesions at the time of surgical examination. The results showed the mean VEGF-A levels were significantly higher in the serum and PF of patients with endometriosis than in the controls. The VEGF-A levels in the serum and PF of patients with severe endometriosis (stages Ⅲ-Ⅳ) were significantly higher than in those with minimal endometriosis (P<0.001). It was concluded that endometriosis was associated with significant modulation in the levels of circulating VEGF-A.
