The Expression of Resistin in Adipose Tissues of Patients with Polycystic Ovary Syndrome and Insulin Resistance
10.1007/s11596-009-0521-6
- Author:
CHU YONGLI
1
;
CUI QING
;
FENG GUIJIAO
;
SONG ZHIYUN
;
JIANG XUEQIANG
Author Information
1. Department of Obstetrics and Gynecology, Yantai Yuhuangding Hospital, Yantai 264000, China
- Keywords:
polycystic ovary syndrome;
resistin;
fasting plasma glucose;
fasting insulin;
insulin resis-tance
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2009;29(5):642-645
- CountryChina
- Language:Chinese
-
Abstract:
The relationship between the expression of resistin in polycystic ovary syndrome (PCOS) and insulin resistance was investigated. The plasma resistin concentrations in 35 patients with PCOS and 40 controls were measured by ELISA. Luteinizing hormone (LH), follicle-stimulating hormone (FSH), and fasting insulin (FIN) were tested by radioimmunoassay. Insulin resistance index (HOMA-IR) was calculated. Fasting plasma glucose (FPG) was determined by oxidase test. Western blot and reverse transcriptase PCR (RT-PCR) methods were used to detect the expression of resistin in adipose tissues.The levels of plasma resistin, LH, LH/FSH and FIN and HOMA-IR in patients with PCOS were sig-nificantly higher than those in control group (all P<0.05). Plasma resistin was correlated positively with FPG, FIN, HOMA-IR, LH and LH/FSH (r=0.56, 0.60, 0.65, 0.48, and 0.42 respectively). Resistin pro-tein and mRNA expression levels in patients with PCOS were significantly higher than those in normal tissues (all P<0.01). It was concluded that resistin might be involved in the pathogenesis of insulin re-sistance of PCOS.
