Study on the association between gene polymorphism of ENPP1 and left ventricular hypertrophy: A Guangzhou Biobank Cohort Study-CVD
10.3760/cma.j.issn.0254-6450.2010.07.005
- VernacularTitle:ENPP1基因多态位点与左心室肥厚的关系研究
- Author:
Ya-Li JIN
1
;
Bin LIU
;
Chao-Qiang JIANG
;
Lin XU
;
Li-Hong GUO
;
Tai-Hing LAM
;
Jie-Ming LIN
;
Wei-Sen ZHANG
;
Kar-Keung CHENG
;
GN THOMAS
Author Information
1. 广州市第十二人民医院
- Keywords:
Left ventricular hypertrophy;
Ectonucleotide pyrophosphatase/phosphodiesterasel;
Polymorphism
- From:Chinese Journal of Epidemiology
2010;31(7):742-746
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the association between genetic polymorphism of rs1409181 in ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and left ventricular hypertrophy (LVH) among older Chinese in Guangzhou. Methods 390 subjects aged ≥50 years were randomly selected from the Guangzhou Biobank Cohort Study-CVD. Information on personal history, blood pressure, fasting plasma glucose and lipids were collected. Color Doppler ultrasound was used to measure the indicators of LVH, including left ventricular internal diastolic diameter (LVIDD) , thickness of the interventricular septum diastolic wall (IVSD) and the posterior wall diastolic diameter (LVPWD). LVIDD was calculated using Devereux ventricular mass (LVM)equation while the Left ventricular mass index (LVMI) equation was used to estimate LVH. The genotype of rs1409181 was determined by Taqman SNP genotyping kits using the ABI 7900HT real time PCR system. Results In the GG, CG and CC genotype groups, the proportions of LVH were 21.5%, 28.2% and 37.5% respectively. Compared with GG, the adjusted odds ratios (95% confidence interval) for the LVH were 1.39(0.78-2.50) and 2.36(1.21-4.60) for CG genotype and CC genotype of ENPP1 respectively (P for trend=0.01). Conclusion Polymorphism of ENPP1 gene rs1409181 was associated with LVH in the older Chinese people in Guangzhou.
