Natural history of HIV infections among injecting drug users in Dehong prefecture, Yunnan province
10.3760/cma.j.issn.0254-6450.2010.07.010
- VernacularTitle:云南省德宏州静脉注射吸毒人群艾滋病毒感染自然史研究
- Author:
Song DUAN
1
;
Lan ZHANG
;
Li-Fen XIANG
;
Yi-Juan DUAN
;
Zhong-Ju YANG
;
Man-Hong JIA
;
Yong ZHANG
;
Xiao-Bo ZHANG
;
Cheng-Hui XI
;
Zhou-Lin LI
;
Run-Hua YE
;
Zhi-Rong LI
;
Hao-Fen ZHANG
;
Hong-Mei ZHANG
;
Wen-Xiang HAN
;
Yue-Cheng YANG
;
Yu-Rong GONG
;
Jie GAO
;
Ning WANG
Author Information
1. 云南省德宏州疾病预防控制中心
- Keywords:
Human immunodeficiency virus;
Injecting drug users;
Natural history;
Incubation period
- From:
Chinese Journal of Epidemiology
2010;31(7):763-766
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the natural history of HIV-1 infection among intravenous drug users (IDUs) detected in late 1989 in the study area and the factors related to survival of these IDUs infected with HIV. Methods 196 injecting drug users first detected during August and December, 1989 were observed in Ruili county, Yunnan province. Data gathered from the 20-year follow-up program was collected and analyzed retrospectively. Results After 20 years' follow-up period, 90.3% of the 196 IDUs with HIV infection died, 5.1% of them were still alive, and 4.6% were lost. The crude pre-AIDS mortality rate was 98.1/1000 person-years, and the AIDS mortality rate was 54.9/1000 person-years. Malaria, septicemia were the main causes of death among the natural diseases whereas overdose and accidental causes were the principal causes related to those non-disease deaths.The median survival time from sero-conversion to death was 8.6 years (95%CI: 7.6-9.7). The median survival time from sero-conversion to death due to AIDS was 11.3 years (95%CI: 10.3-12.8) with the incubation time as around 10.3 years. People older than 30 years at seroconversion and length of drug usage were associated with shorter survival time, with hazards ratios as 1.9 and 0.7, respectively.Conclusion A high pre-AIDS mortality was observed among IDUs. Both the median survival time from sero-conversion to death and the HIV incubation period were shorter than that observed in the developed countries. Age of HIV infection seemed to have a strong effect on survival.
