Mediation of abdominal obesity on the association between cigarette smoking and β-cell function

VernacularTitle:中心型肥胖在吸烟与β细胞功能关系中的中介效应
Author: Tao LIU ¹ ; Hui WANG ; Quan QIU ; Li-Li TAN ; Wei CHEN ; Xue-Qing YU ; Xiao-Li SUN ; Wei-Qing CHEN
Author Information

1. 中山大学
Keywords: Abdominal obesity; Cigarette smoking; β-cell function; Mediation effect
From:Chinese Journal of Epidemiology 2010;31(9):988-991
CountryChina
Language:Chinese
Abstract: Objective To confirm the effect of cigarette smoking on β-cell function, and further investigate the mediation effect of abdominal obesity. Methods Participants would include 1440 Chinese smokers who had participated in a community-based chronic disease screening project in Guangzhou and Zhuhai from 2006 to 2007. They were interviewed with structured questionnaire on their socio-demographic status and smoking behaviors. Waist-to-hip ratio (WHR) and fasting serum C-peptide concentration were also measured. Results After adjustment for the potential confounding factors, when compared with smokers with consumption 1-10 cigarettes/day, smokers with consumption of 11-20 cigarettes/day (adjusted OR=1.53, 95%CI: 1.22-1.90) or ＞20 cigarettes/day (adjusted OR=1.92, 95%CI: 1.32-2.79) had significant higher risks to get C-peptide concentration larger than its median. Furthermore, 37.54% of the effect of cigarette smoking on C-peptide concentration was partially mediated by abdominal obesity. Conclusion Cigarette smoking might be a risk factor for β-cell dysfunction and abdominal obesity.