The effect of HJ-1 NO--HFJV respirator on treating pulmonary edema caused by seawater drowning.
- Author:
Yanrong FAN
1
;
Wendu DONG
;
Jingjin HE
;
Li DU
;
Genxing XU
;
Xinjuan LIU
;
Yun PEI
;
Gengfeng FU
;
Guohua MA
Author Information
1. Institute of Molecular Medicine, Nanjing Military Medical College, Nanjing 210099.
- Publication Type:Journal Article
- MeSH:
Animals;
Disease Models, Animal;
High-Frequency Jet Ventilation;
instrumentation;
Near Drowning;
complications;
Nitric Oxide;
therapeutic use;
Pulmonary Edema;
etiology;
therapy;
Rabbits
- From:
Journal of Biomedical Engineering
2002;19(3):526-528
- CountryChina
- Language:Chinese
-
Abstract:
The study was to observe the therapeutic effect of HJ-1 NO--HFJV respirator on treating pulmonary edema caused by seawater drowning. Seawater was infused into the rabbit's lung to establish the animal model of pulmonary edema caused by seawater drowning(PE-SWD). Then the animals were divided into three groups: simple PE-SWD model as control group, treat group(animal model treated with HFJV respirator and four medicines) and HFJV respiratior plus NO group. Pao2, Sao2 and pH were measured by the blood-gas analyzer. The survival time and seawater drowing-respiratiory distress syndrom(SW-RDS) were observed. The results showed that Pao2, Sao2 in NO group were remarkably higher than that of PE-SWD control group, and the survival time was longer than that of medicine treated group and the incidence of SW-RDS decreased to zero. We assume that HJ-1 NO-HFJV respirator is efficient on treating pulmonary edema.
