Elimination of methylene blue in plasma by use of adsorbents.
- Author:
Yu MA
1
;
Xiaolan YANG
;
Xianjue TANG
;
Shuhua JING
Author Information
1. Department of Chemistry, Chongqing University of Medical Sciences, Chongqing 400016.
- Publication Type:Journal Article
- MeSH:
Adsorption;
Agar;
chemistry;
Animals;
Charcoal;
chemistry;
Hemofiltration;
instrumentation;
Humans;
In Vitro Techniques;
Methylene Blue;
isolation & purification;
Rabbits
- From:
Journal of Biomedical Engineering
2003;20(1):11-13
- CountryChina
- Language:Chinese
-
Abstract:
The adsorption of methylene blue (MB) in plasma on cross-linked agarose beads entrapped activated charcoal (CAAC-I), cross-linked agarose coated activated charcoal (CAAC-II) and cross-linked agar beads entrapped attapulgite (CAA) was tested in this study. These adsorbents are intended to be applied to blood purification for eliminating MB from virucidal MB-phototrated plasma units. The experimental results indicated that the adsorption of MB in plasma on CAAC-I and CAA was quick and efficacious, but it was slower on CAAC-II. The relationship between the adsorption time and the adsorption rate was examined with reference to the plasma with a specific concentration of MB flowing over a certain volume of CAA. A flow rate of about 1 ml.min-1 through 10 ml CAA at 25 degrees C could eliminate more than 95% of the MB in 200 ml human plasma (1 mumol.L-1).
