Two sorts of problems on drug controlled release from swellable polymer.
- Author:
Lingbing LI
1
;
Yebang TAN
Author Information
1. Department of Pharmaceutics, Shandong University, Jinan 250012. cn-lbli@263.net
- Publication Type:Journal Article
- MeSH:
Delayed-Action Preparations;
Diffusion;
Drug Delivery Systems;
Models, Chemical;
Polymers;
chemistry;
Tablets
- From:
Journal of Biomedical Engineering
2003;20(1):17-21
- CountryChina
- Language:Chinese
-
Abstract:
The mechanism of drug release from swellable polymer was studied. The model which can explain the drug release from glassy polymer was developed by coupling drug diffusion equation and solvent diffusion equation. The effect of viscoelastic stress of polymer was also considered. The Deborah number and swelling interface number were used to describe the mechanism of drug release, especially relax controlled mechanism.
