Preparation of complex chitosan microcapsule and its application in controlled release of vitamin D2.
- Author:
Xinyuan SHI
1
;
Tianwei TAN
Author Information
1. College of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029.
- Publication Type:Journal Article
- MeSH:
Capsules;
Cellulose;
analogs & derivatives;
pharmacology;
Chitin;
analogs & derivatives;
pharmacology;
Chitosan;
Delayed-Action Preparations;
Drug Compounding;
Drug Delivery Systems;
Ergocalciferols;
pharmacology;
In Vitro Techniques
- From:
Journal of Biomedical Engineering
2003;20(1):26-29
- CountryChina
- Language:Chinese
-
Abstract:
In this work a system which consists of chitosan (CS) microcores entrapped within enteric polymer is presented. Vitamin D2, used as a model drug, was efficiently entrapped within CS microcores using spray-drying and then microencapsulated into ethylic cellulose(EC). The morphology and release properties of microcapsules were tested. The influential factors of preparation conditions included molecular weight of chitosan, concentration of chitosan solution, concentration of acetic acid, loading of vitamin D2 were discussed. The results of in vitro release studies showed that the microcapsules prepared in this article could realize sustained release in intestine.
