A follow-up study about 52 cases of atypical lobular hyperplasia and lobular carcinoma in situ of the breast.
- Author:
Hong-Yuan LI
1
;
Guo-Sheng REN
;
Nasrin ARNOULD
;
Jean-Philippe BRETTES
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Breast Neoplasms; etiology; pathology; surgery; Carcinoma in Situ; etiology; pathology; surgery; Female; Fibrocystic Breast Disease; etiology; pathology; surgery; Follow-Up Studies; Humans; Middle Aged; Retrospective Studies; Risk Factors
- From: Chinese Journal of Surgery 2007;45(13):874-876
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the biological behavior and treatment method for the breast atypical lobular hyperplasia (ALH) and breast lobular carcinoma in situ (LCIS).
METHODSSeventeen cases of ALH and thirty-five cases of LCIS were reviewed from July 1982 to January 1996. All cases were followed by physical examination, mammography and B-ultrasound for an average of 146.6 months (range, 3 - 257 months).
RESULTSMost cases of ALH and LCIS occurred before menopause (about 69.2%). Fifty-two cases of ALH and LCIS were occasionally verified pathologically after surgery for benign diseases. The microcalcification with ALH and LCIS had been detected in 25 cases, accounted for 48.1%. Eight cases of ALH/LCIS became invasive carcinoma. There were 5 cases in the same breast, 3 cases in the contralateral breast; The subsequent breast cancer occurred longer than nine years after ALH/LCIS was diagnosed. The family history of breast carcinoma and ovary carcinoma occurred in 4 cases of breast carcinoma, accounted for 50%, but it was no significant (P > 0.05). Also, there was no difference between LCIS and ALH, which occurred the breast carcinoma (P > 0.05).
CONCLUSIONThe excisional biopsy might be necessary to ALH and LCIS.
