Efficacy and safety evaluation of glucosamine hydrochloride in the treatment of osteoarthritis.
- Author:
Wei-bin ZHANG
1
;
Cheng-yu ZHUANG
;
Jian-min LI
;
Zhi-ping YANG
;
Xiao-liang CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Double-Blind Method; Female; Glucosamine; therapeutic use; Humans; Male; Osteoarthritis, Hip; drug therapy; Osteoarthritis, Knee; drug therapy; Treatment Outcome
- From: Chinese Journal of Surgery 2007;45(14):998-1001
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the efficacy and safety of glucosamine hydrochloride for the treatment of osteoarthritis.
METHODSA multi-central, randomized, controlled clinical trial of glucosamine hydrochloride comparing glucosamine sulfate for the treatment of osteoarthritis was performed. One hundred and forty-three patients suffering from knee or hip osteoarthritis were randomized into study (glucosamine hydrochloride) or control (glucosamine sulfate) group. Patients in study group orally took glucosamine hydrochloride 2 times daily for 6 weeks, each time 1 capsule, and those in control group took glucosamine sulfate 3 times daily for 6 weeks also, each time 2 capsules.
RESULTSThe symptomatic improvement of joint pain at walking, at rest and stiffness after 6 week treatment with glucosamine hydrochloride was better than those with glucosamine sulfate. The results had significant difference (P < 0.05). Total effective rates of patients with glucosamine hydrochloride was 75.4% and 60.6% with glucosamine sulfate, but no statistical difference. The results suggested both glucosamine had the considerable efficacy in the treatment of osteoarthritis. Three cases in study group and 2 in control group reported mild adverse events. No severe adverse events (SAE) was observed.
CONCLUSIONGlucosamine hydrochloride is as effective and safe as glucosamine sulfate for the treatment of osteoarthritis.