A new model for survival assessment based on the Chinese liver transplantation patients with hepatocellular carcinoma.
- Author:
Ming ZHANG
1
;
Bo LI
;
Fei YIN
;
Lü-Nan YAN
;
Yong ZENG
;
Tian-Fu WEN
;
Ji-Chun ZHAO
;
Yan-Li LUO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Alkaline Phosphatase; blood; Carcinoma, Hepatocellular; blood; surgery; China; Feasibility Studies; Female; Humans; Liver Neoplasms; blood; surgery; Liver Transplantation; Male; Middle Aged; Outcome Assessment (Health Care); methods; Proportional Hazards Models; Reproducibility of Results; Sodium; blood; Survival Analysis; alpha-Fetoproteins; analysis
- From: Chinese Journal of Surgery 2007;45(15):1023-1026
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo establish a new model for liver transplantation recipients with hepatocellular carcinoma (HCC) and validate the feasibility of it.
METHODSFrom February 1999 to June 2005, clinical data of 130 liver cancer patients who accepted liver transplantation were collected. Screening the pretransplant factors correlated with post-transplant survival using COX proportional-hazards regression, and establishing the assessment model. Finally, the area under the receiver operating characteristic curve (AUC ROC) were used to compare the validity of the new model with MELD.
RESULTSScreened by the COX model, serum concentrations of alkaline phosphatase, alphafetoprotein, sodium and the number of tumor nodule were significantly related with post-transplant survival. The new model with these four variables had greater ability to assess post-transplant recipients' outcomes, however, the MELD had not evaluation capacity.
CONCLUSIONThe established new model has a better ability to assess the risk of post-transplant mortality.
