Expression and clinical significance of matrix metalloproteinase in gastric stromal tumor.
- Author:
Rui-zheng MIAO
1
;
Yue-ping LI
;
Yong-kang WANG
;
Xiao-bo YU
;
Min ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Female; Follow-Up Studies; Gastrointestinal Stromal Tumors; enzymology; pathology; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Matrix Metalloproteinase 2; biosynthesis; Matrix Metalloproteinase 9; biosynthesis; Middle Aged; Prognosis; Stomach Neoplasms; enzymology; mortality; pathology; Survival Rate
- From: Chinese Journal of Surgery 2007;45(17):1196-1198
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression and clinical significance of matrix metalloproteinase (MMP) in gastric stromal tumor (GST).
METHODSMMP-2 and MMP-9 expression were determined by immunohistochemistry in tumor tissues in 44 patients with GST, and their relationship with clinicopathologic factors of the neoplasm was also investigated.
RESULTSMMP-2 and MMP-9 were expressed in the cytoplasm in 84.1% (37/44) and 81.8% (36/44) of tumors, respectively. The positive rates of MMP-2 and MMP-9 increased significantly in parallel to the increase in tumor malignancy (P < 0.05) and associated with pattern of tumor growth, tumor size, and centre necrosis (P < 0.05). In addition, there was a statistically significant positive correlation between the expression of the two markers in GST (r = 0.6523, P < 0.05). Furthermore, the 5-year postoperative survival rates of patients with positive expressions of MMP-2 and MMP-9 were significantly lower than those of patients with negative expressions of the two markers (P < 0.05).
CONCLUSIONOver expression of MMP-2 and MMP-9 can be served as objective markers to judge the malignant degree and, to predict the prognosis of patients with GST.
