Effects of ruthenium red on body temperature in rats with lipopolysaccharide-induced fever.
- Author:
Lan-lan WANG
1
;
Yu CAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blotting, Western; Body Temperature; drug effects; Dose-Response Relationship, Drug; Fever; chemically induced; metabolism; physiopathology; Hypothalamus; drug effects; metabolism; Lipopolysaccharides; Male; Rats; Rats, Sprague-Dawley; Ruthenium Red; pharmacology; TRPV Cation Channels; biosynthesis
- From: Journal of Southern Medical University 2008;28(8):1376-1377
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of ruthenium red (RR) on the body temperature of rats with lipopolysaccharide (LPS)-induced fever and investigate the possible mechanism.
METHODSRat models of fever were established with lipopolysaccharide and the effects of RR at different doses were observed on the body temperature of the rats and the content of TRPV4 in the hypothalamus.
RESULTSCompared with those in LPS group, the rats with LPS-induced fever receiving RR treatment showed a dose-dependent lowering of the body temperature. The rats with RR treatment had lower body temperature than those with saline injection. The content of TRPV4 in the saline group was significantly higher than that in RR+LPS and RR group.
CONCLUSIONSRR inhibits LPS-induced fever in rats and regulates the hypothalamal expression of TRPV4 channels, which may participate in the maintenance of normal body temperature.
