Effect of Danshen root compound on blood lipid and bone biomechanics in mice with hyperlipemia-induced osteoporosis.
- Author:
Zhi-ping ZHANG
1
;
Ting-ting YOU
;
Li-yi ZOU
;
Tie WU
;
Yi WU
;
Liao CUI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Biomechanical Phenomena; Bone and Bones; drug effects; metabolism; physiopathology; Drugs, Chinese Herbal; pharmacology; therapeutic use; Female; Hyperlipidemias; complications; drug therapy; Lipids; blood; Male; Mice; Osteoporosis; blood; etiology; prevention & control; Phenanthrolines; pharmacology; therapeutic use; Phytotherapy; Salvia miltiorrhiza; chemistry
- From: Journal of Southern Medical University 2008;28(9):1550-1553
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effects of Danshen root compound (DSC) on blood lipid and bone biomechanics in mice with hyperlipemia-induced osteoporosis.
METHODSForty Kunming mice were randomized into 5 equal groups, and were given intragastric administration with distilled water (control), lipid emulsion (LE) at the daily dose of 5 ml/kg, LE plus simvastatin, LE plus DSC at 5.0 g/kg (DSC-L group), and LE plus DSC at 10.0 g/kg (DSC-H group), respectively. Serum TC, TG, and HDL-c levels and left femur hydroxyproline, calcium and phosphate contents were measured in the rats, with the right femur taken for bone biomechanical test.
RESULTSCompared with those in the control group, serum TC, LDL-c and AI of the mice increased and HDL-c, Hyp and bone calcium decreased significantly (P<0.01) with lowered bone biomechanical properties. Compared with those of the LE model group, AI decreased and HDL-c increased significantly in DSC-L and DSC-H groups (P<0.01), and the bone biomechanics in DSC-H group was improved.
CONCLUSIONLong-term intragastric administration of lipid emulsion causes lipid metabolic disorder and induces osteoporosis due to hyperlipemia in mice. DSC can significantly increase HDL-c and partially prevent the occurrence of osteoporosis in mice.
