Efficacy and toxicity of trastuzumab combined vinorelbine in 21 patients with HER2 overexpressing metastatic breast cancer.
- Author:
Ning-ning ZHOU
1
;
Dong-geng LIU
;
Xiao-yu TENG
;
Wen-qi JIANG
Author Information
- Publication Type:Clinical Trial
- MeSH: Adult; Aged; Anemia; chemically induced; Antibodies, Monoclonal; administration & dosage; adverse effects; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; adverse effects; therapeutic use; Breast Neoplasms; drug therapy; metabolism; pathology; Carcinoma, Ductal, Breast; drug therapy; metabolism; pathology; Female; Humans; Middle Aged; Nausea; chemically induced; Neoplasm Metastasis; Receptor, ErbB-2; metabolism; Survival Analysis; Thrombocytopenia; chemically induced; Trastuzumab; Treatment Outcome; Vinblastine; administration & dosage; adverse effects; analogs & derivatives; Vomiting; chemically induced
- From: Journal of Southern Medical University 2008;28(9):1707-1709
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the efficacy and toxicity in patients with HER2 overexpressing metastatic breast cancer.
METHODSTwenty-one patients with HER2 overexpressing metastatic breast cancer entered into the study. Trastuzumab (8 mg/kg day 1, then 6 mg/kg every 21 days or 4 mg/kg, then 2 mg/kg every week) and vinorelbine (25 mg/m(2)) was given on days 1 and 8 every 21 days.
RESULTSOverall 56 cycles were given to the 21 patients enrolled into the study (mean 2, range 1-6). All can be evaluated. The response rate was 33.33% (7/21), one patient achieved complete response (CR), six patients achieved partial response (PR), four patients achieved stable disease (SD), ten patients achieved progressive disease (PD)]. The median time to progression was 3.5 months. One year overall survival was 33%. The major toxicity was myelosuppression and peripheral neuritis. A few patients were observed with fever and lower grade cardiac failure.
CONCLUSIONThe combination of trastuzumab and vinorelbine is an effective and well tolerated therapy in patients with pretreated metastatic breast cancer.
