Drug-induced kidney disease--pathology and current concepts.
- Author:
Alwin H L LOH
1
;
Arthur H COHEN
Author Information
1. Department of Pathology, Singapore General Hospital, Singapore. loh.hwai.liang@sgh.com.sg
- Publication Type:Journal Article
- MeSH:
Humans;
Kidney Diseases;
chemically induced;
pathology
- From:Annals of the Academy of Medicine, Singapore
2009;38(3):240-250
- CountrySingapore
- Language:English
-
Abstract:
The kidneys can be damaged by a large number of therapeutic agents. The aim of this article is to discuss the pathological features of drug-induced renal disease as diagnosed by kidney biopsy. The literature is reviewed and cases seen by the authors that have a known drug association are analysed. Mechanisms of injury are varied and all renal structures may be affected. The tubulointerstitial compartment is most frequently involved, but glomerular and vascular lesions are seen in a significant proportion of cases.
