Cognitive dysfunction in schizophrenia: a perspective from the clinic to genetic brain mechanisms.
- Author:
Hao Yang TAN
1
Author Information
1. Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892-1364, USA. tanh@mail.nih.gov
- Publication Type:Journal Article
- MeSH:
Cognition Disorders;
etiology;
genetics;
Dopamine;
genetics;
Glutamic Acid;
genetics;
Humans;
Magnetic Resonance Imaging;
Neurosciences;
Schizophrenia;
genetics;
physiopathology
- From:Annals of the Academy of Medicine, Singapore
2009;38(5):420-425
- CountrySingapore
- Language:English
-
Abstract:
Schizophrenia is a brain disease with differing symptomatic presentations, outcomes, and complex genetic mechanisms. A selection of recent work integrating clinical observations, human brain imaging and genetics will be reviewed. While the mechanics of brain dysfunction in schizophrenia remains to be well understood, the emerging evidence suggests that a number of interacting genetic mechanisms in dopaminergic and glutamatergic systems affect fundamental disease-related cognitive brain processes and may do so early in disease neurodevelopment. The availability of new imaging and genetic technologies, and institutional support for research in the translational neurosciences, extends the hope that increased understanding of these brain processes could yield meaningful clinical applications.
