Immunological mechanism of wheezing attack in children with cytomegalovirus infection.
- Author:
Xiao-Hua ZHU
1
;
Qiang CHEN
;
Qiu-Gen LI
;
Lan LI
;
Jiang-Wei KE
;
Zhi-Qiang LIU
;
Fei RAN
Author Information
- Publication Type:Journal Article
- MeSH: Child, Preschool; Cytokines; blood; Cytomegalovirus Infections; immunology; Female; Humans; Infant; Male; Respiratory Sounds; etiology; immunology; T-Lymphocytes, Regulatory; immunology; Th17 Cells; immunology
- From: Chinese Journal of Contemporary Pediatrics 2016;18(9):831-834
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the possible immunological mechanism of wheezing attack in children with cytomegalovirus (CMV) infection.
METHODSA total of 25 under-5-year-old children with wheezing following CMV infection were enrolled. The expression of serum regulatory T cells (Treg)/T helper 17 (Th17) cytokines interleukin (IL)-10, IL-6, and IL-17, and peripheral blood lymphocyte subsets were determined. Twenty age-matched healthy children were selected as the control group.
RESULTSThe wheezing group had a significantly reduced serum IL-10 level, significantly increased IL-6 and IL-17 levels, significantly reduced levels of natural killer cells, and significantly increased levels of CD8+ T cells and CD19+ B cells, as compared with the control group.
CONCLUSIONSWheezing children with CMV infection have Treg/Th17 imbalance and cellular immune dysfunction, which may be an important immunological mechanism of the development of wheezing in children after CMV infection.
