Application of Mycoplasma pneumoniae antibody and load index in the diagnosis of Mycoplasma pneumoniae pneumonia in children.
- Author:
Hui XIE
1
;
Ji-Ming LI
;
Hui-Fen ZHANG
;
Ye WANG
;
Li-Lin ZHONG
;
Qing-Rong LIAN
;
Hong-Ba DONG
Author Information
- Publication Type:Journal Article
- MeSH: Antibodies, Bacterial; blood; Child; Child, Preschool; DNA, Bacterial; analysis; Early Diagnosis; Female; Humans; Infant; Male; Pneumonia, Mycoplasma; diagnosis; microbiology
- From: Chinese Journal of Contemporary Pediatrics 2016;18(10):984-987
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the role of Mycoplasma pneumoniae (MP) load and antibody measurements in the diagnosis of MP pneumonia.
METHODSA total of 115 children with MP pneumonia and 400 healthy children were enrolled. The MP load and total antibody level were measured at different stages, and the MP load index (MPLI) was calculated.
RESULTSThe cut-off value of MPLI for MP infection was 6.12. MPLI and total antibody titer increased during the course of the disease, while MP-DNA decreased rapidly. Within the same time of blood collection, the group with a higher MP load had a significantly higher total antibody titer than the group with a lower MP load (P<0.05). Within 2 weeks of the course of the disease, the negative antibody group had a significantly higher MPLI than the positive antibody group (P<0.05).
CONCLUSIONSMPLI provides a standardized quantitative value of MP-DNA and plays an important role in the early diagnosis of MP infection.
