Clinical effect of high-frequency oscillatory ventilation combined with pulmonary surfactant in treatment of neonatal severe meconium aspiration syndrome complicated by pulmonary hemorrhage.
- Author:
Jing HUANG
1
;
Xin-Zhu LIN
;
Zhi ZHENG
Author Information
- Publication Type:Journal Article
- MeSH: Combined Modality Therapy; Female; Hemorrhage; therapy; High-Frequency Ventilation; Humans; Infant, Newborn; Lung Diseases; therapy; Male; Meconium Aspiration Syndrome; complications; drug therapy; Pulmonary Surfactants; therapeutic use
- From: Chinese Journal of Contemporary Pediatrics 2016;18(11):1075-1079
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinical effect and safety of high-frequency oscillatory ventilation (HFOV) combined with pulmonary surfactant (PS) in the treatment of neonatal severe meconium aspiration syndrome (MAS) complicated by neonatal pulmonary hemorrhage (NPH).
METHODSA total of 48 children with severe MAS complicated by NPH were enrolled, and a retrospective analysis was performed for the clinical effects of HFOV+PS (trial group, 25 children) and HFOV alone (control group, 23 children). The blood gas parameters, oxygenation index (OI), PaO/FiO(P/F) value, duration of pulmonary hemorrhage, ventilation time, length of hospital stay, incidence of complications, and outcome were compared between the two groups.
RESULTSAt 6, 12, 24, and 48 hours after treatment, the trial group had significantly better PaO, OI, and P/F value than the control group (P<0.05). Compared with the control group, the trial group had significantly shortened ventilation time and duration of pulmonary hemorrhage (P<0.05). There were no significant differences in the length of hospital stay, the incidence of complications, and cure rate between the two groups (P>0.05).
CONCLUSIONSHFOV combined with PS can better improve oxygenation function and shorten the duration of NPH and ventilation time. Meanwhile, it does not increase the incidence of adverse events. Therefore, it is a safe and effective therapy.