Association between tumor necrosis factor-α G-308A polymorphisms and genetic susceptibility to spontaneous preterm birth.
- Author:
Wei PENG
1
;
Xiao YANG
;
Li-Na ZHU
;
Xiao-Ai ZHANG
;
Yan WANG
Author Information
- Publication Type:Journal Article
- MeSH: Female; Genetic Predisposition to Disease; Genotype; Humans; Infant, Newborn; Male; Polymorphism, Single Nucleotide; Premature Birth; genetics; Tumor Necrosis Factor-alpha; genetics
- From: Chinese Journal of Contemporary Pediatrics 2016;18(12):1247-1253
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the association between tumor necrosis factor-α (TNF-α) G-308A polymorphisms and genetic susceptibility to spontaneous preterm birth (SPTB).
METHODSThe case group enrolled 753 SPTB infants and the control group included 681 term infants. TNF-α G-308A polymorphisms were genotyped using Sequenom MassARRAY®SNP.
RESULTSThe frequencies of the allele (G and A) in the case and control groups were not significantly different (P=0.35). The frequencies of the genotypes (GG, GA and AA) in the case and control groups were not significantly different (P=0.64). The logistic regression analysis found that TNF-α G-308A was not associated with genetic susceptibility to SPTB (OR=0.85; 95%CI: 0.61-1.19; P=0.35).
CONCLUSIONSThere is no association between the polymorphisms of TNF-α G-308A and the genetic susceptibility to SPTB.
