Clinical study of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation.
10.7534/j.issn.1009-2137.2014.05.036
- Author:
Jun HE
1
;
Bao-An CHEN
2
;
Ming NI
3
;
Xue WU
3
;
Jia-Hua DING
3
Author Information
1. Department of Hematology(Key Discipline of Medicine of Jiangsu Province), Zhongda Hospital Affiliated to Southeast University Medical College, Nanjing 210009, Jiangsu Province, China. Department of Laboratorial Examination, Nanjing Occupational Disease Prevention and Treatment Hospital, Nanjing 210004, Jiangsu Province, China.
2. Department of Hematology(Key Discipline of Medicine of Jiangsu Province), Zhongda Hospital Affiliated to Southeast University Medical College, Nanjing 210009, Jiangsu Province, China. E-mail: cba8888@hotmail.com.
3. Department of Hematology(Key Discipline of Medicine of Jiangsu Province), Zhongda Hospital Affiliated to Southeast University Medical College, Nanjing 210009, Jiangsu Province, China.
- Publication Type:Journal Article
- MeSH:
Allografts;
Cytomegalovirus Infections;
etiology;
Graft vs Host Disease;
Hematopoietic Stem Cell Transplantation;
adverse effects;
Humans;
Risk Factors;
Transplantation Conditioning
- From:
Journal of Experimental Hematology
2014;22(5):1371-1376
- CountryChina
- Language:Chinese
-
Abstract:
This study was purposed to investigate the cytomegalovirus (CMV) infection and its related factors after allogenic hematopoietic stem cell transplantation (allo-HSCT). A total of 108 patients who received allo-HSCT in zhongda hospital from January 1, 2004 to March 31, 2014 were enrolled in this study. The CMV infection rate and the median time when the CMV-DNA was positive for the first time, and the risk factors related with CMV infection, CMV disease distribution and mortality after allo-HSCT were analyzed. The results showed that the infection rate of CMV was 52.78% (57/108), the median time of CMV infection was 44 d, especially during 30 d-100 d after transplantation. The univariate analysis showed that CMV infection rate was related with the HLA-identical situation between the donor and the recipient, and whether the use of anti-human thymus globulin(ATG) in conditioning regimen, neutropenic period after transplantation exceeded 10 d and graft-versus-host disease (GVHD). Multivariate analysis showed that CMV infection rate was related with neutropenic period longer than 10 d after transplantation and graft-versus-host disease (GVHD). The mortality of the patients with CMV disease was 58.82% (10/17), in which the mortality of CMV interstitial pneumonia was highest. The CMV infection was one of the most commonly happened infection after allo-HSCT. It is concluded that to reduce the incidence of CMV disease and mortality, the best choice of allo-HSCT is HLA-identical donor, ATG should be used during the conditioning process, and neutropenic period should be reduced less than 10 days. Moreover, it is necessary to strengthen the preemptive therapy of CMV infection actively.
